It has also been found to reduce the severity of 'hot flashes' in menopausal women and men on hormonal therapy for the treatment of prostate cancer. It may work on pain via effects on the opioid receptor.
Venlafaxine has been used off label for the treatment of diabetic neuropathy and migraine prevention (in some people, however, venlafaxine can exacerbate or cause migraines). Venlafaxine is used primarily for the treatment of depression, general anxiety disorder, social phobia, panic disorder, and vasomotor symptoms. In 2019, it was the 40th most commonly prescribed medication in the United States with more than 17 million prescriptions. Venlafaxine was approved for medical use in the United States in 1993. How it works is not entirely clear, but it seems to be related to the potentiation of the activity of some neurotransmitters in the brain. There are concerns that use during the later part of pregnancy can harm the baby. Antidepressant withdrawal syndrome may occur if stopped. Severe side effects include an increased risk of suicide, mania, and serotonin syndrome. Ĭommon side effects include loss of appetite, constipation, dry mouth, dizziness, sweating, and sexual problems. It is used to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder, and social phobia. Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
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